The symptoms can be the same as other medical conditions, so it can be hard to diagnose. This may be difficult if marijuana is being used as an appetite stimulant or for treatment of chemotherapy-induced nausea and vomiting. If willing, patients should be referred to a substance abuse rehabilitation center.

1. Prodromal Phase

Further, these behaviors could also be noted in CVS, preadolescents, and adolescents with no prior exposure to cannabis 8. These changes from hot bathing are probably not specific to CHS but can be seen across all functional nausea and vomiting disorders, including CVS, and are probably aggravated by cannabis use 9. Thus, hot shower bathing may be more closely related to CHS, but is neither specific nor sensitive in its diagnosis. This is probably the reason for its non-inclusion in the Rome IV diagnostic criteria for CHS.

Only improvement after quitting marijuana confirms the diagnosis. A specialist trained in diseases of the digestive tract (gastroenterologist) might make the diagnosis. In older patients, especially those with hypertension, cardiovascular illnesses such as aortic pathology and atypical coronary artery syndromes may present as vague abdominal pain, nausea, what is Oxford House and vomiting.

A study evaluating the TCA effect on CVS with CHS indicated that both conditions showed significant pain relief 5. The CHS group achieved a 70% improvement, and the CVS group achieved an 80% improvement following the treatment with amitriptyline 5. CB2 receptors help to control inflammation, visceral pain, and intestinal motility 34. They are found in lamina propria plasma cells and activated macrophages. Nausea and vomiting are regulated in ECS through central and peripheral pathways 35.

Care Agreement

And a 2022 Canadian study found that ER visits for CHS-related problems had increased 13-fold between 2014 and 2021. (Recreational use and sale of cannabis in Canada was legalized starting in 2018). It’s not clear what percentage of all heavy marijuana users have experienced CHS. If you need help quitting, speak to a healthcare provider or connect with your local addiction treatment services.

Public Health Considerations

The orthosteric ligands of the CB1R were considered to be potential pharmaceuticals in the treatment of disorders such as drug addiction, obesity, and pain 33. However, cannabinoid receptor activation results in adverse psychoactive effects (including depression and suicidal thoughts), which is concerning for them in clinical use 104. With more research, the complexity of allostery can be elucidated, which will be beneficial in the development of safe and efficacious drugs with no neuropsychiatric side effects.

With cannabis use increasing throughout the world as the threshold for legalization becomes lower, its user numbers are expected to rise over time. Despite this trend, a strict criterion for the diagnosis of CHS is lacking. Early recognition of CHS is essential to prevent complications related to severe volume depletion. The recent body of research recognizes that patients with CHS impose a burden on the healthcare systems. Understanding the https://ecosoberhouse.com/article/methadone-withdrawal-symptoms-and-treatment/ pathophysiology of the endocannabinoid system (ECS) remains central in explaining the clinical features and potential drug targets for the treatment of CHS.

Cannabinoid Hyperemesis Syndrome (CHS) and Cyclic Vomiting Syndrome (CVS)

• Multiple studies report pathological frequent and prolonged hot shower behaviors with CHS.
• Early recognition of CHS is essential to prevent complications related to severe volume depletion.
• It’s a serious medical problem that can cause major health issues if you leave it untreated.
• It tends to affect people who use cannabis at least once a week and happens more often in adults who’ve been using cannabis since their adolescent years.
• This constellation of genetic susceptibilities may represent a valid diagnostic tool for identifying at-risk individuals.

Hyperemesis cannabis syndrome is directly linked to long-term cannabis use, while CVS is not related to cannabis. People with CVS may have other triggers like migraines or stress, but their symptoms do not improve by stopping cannabis use, unlike those with CHS. However, CHS presents a unique challenge for regular cannabis users, and understanding this syndrome is crucial for recognizing its signs and seeking proper treatment.

How can I prevent CHS?

Success lies in picking the right products, dosing wisely, and considering terpenes. A 2021 study in Gut Microbes found that CBD altered gut bacteria in mice, reducing inflammation and supporting digestion (Farrimond et al., 2021). Terpenes, the plant’s aromatic compounds, add another layer; limonene, for example, may boost bile flow, easing bloating. These differences showcase cannabis’s versatility; one plant, multiple outcomes, tailored by its chemical profile.

• However, researchers have yet to determine the cause of CHS since it does not affect all users of marijuana.
• Nevertheless, it is essential to be aware of the adverse effects of benzodiazepine, such as oversedation, hypoventilation, dizziness, confusion, incoordination, and the long-term effects of addiction.
• But in the digestive tract, marijuana seems to have the opposite effect.
• The hot temperature affects a part of the brain called the hypothalamus, which regulates temperature and throwing up.

Though the precise mechanisms remain unclear, higher amounts of marijuana consumption, genetic influences, and psychological stress lead to intoxication and paradoxically promote vomiting. To help you transition to the recovery phase, you can try a few home remedies such as regular hot baths. But too many of them may increase your risk for dehydration due to sweating.